Welcome to the HAPIN Trial

The Household Air Pollution Intervention Network (HAPIN) Trial is an international multi-center study aimed at assessing the impact of a liquefied petroleum gas (LPG) cooking stove and fuel intervention on health. HAPIN Trial centers are located in four countries: Guatemala, India, Peru and Rwanda.

The HAPIN Trial was launched in 2017 and will continue at least through 2021. More than 7,200 study participants will help the HAPIN Trial find answers to questions about LPG cookstoves and health.

The trial is funded by the National Institutes of Health (NIH) and the Bill & Melinda Gates Foundation.  Participating NIH components are the National Heart, Lung, and Blood Institute (NHLBI), the National Cancer Institute, the Eunice Kennedy Shriver National Institute of Child Health and Human Development, the National Institute of Environmental Health Sciences, the NIH Common Fund of the NIH Office of the Director, and the Fogarty International Center.  NHLBI leads administration of the trial on behalf of the consortium. The Global Alliance for Clean Cookstoves and the Global LPG Partnership provide expert advice to the consortium.

In Memoriam - Kirk R. Smith

We deeply regret to note the recent sudden passing of our dear friend and HAPIN co-investigator, Professor Kirk R. Smith, in June 2020. Kirk was the universally recognized father of efforts to understand and mitigate the effects of household air pollution on vulnerable populations. He was the first to characterize the contribution that HAP makes to the global burden of disease and to conduct a trial on a possible intervention (RESPIRE). He worked tirelessly to characterize the threat, develop interventions, and advocate for clean cooking solutions, including clean fuels of the type we are investigating in HAPIN. He has been exceptionally effective on all these fronts.

Certainly, millions of women in India and around the world are cooking with cleaner stoves and fuels today because of his world class research and passionate advocacy over decades. Kirk also mentored numerous scientists, including his own students, collaborators, more than a few program officers at NIH, as well as practitioners and policy makers around the world. It is no exaggeration to say that many of us might be spending our professional lives in different ways today were it not for his creativity, his drive, his charisma and his persistence. Some scientists really do change the world.

As requested by his family, if you wish to do something in memory of Kirk, please consider donating to an organization or cause that you feel reflects Kirk's values and commitment to humanity and the world.  

Kirk will be greatly missed but will continue to inspire our research.

- The HAPIN Team


Numerous articles and obituaries have been written about Kirk's life: